Researcher from the Division of Tropical Parasitology is co-author of the publication in "Nature"

5.04.2024

Dr. Habil. Ravi Kant from the Division of Tropical Parasitology of the Medical University of Gdańsk is co-author of the article Ancestral allele of DNA polymerase gamma modifies antiviral tolerance which has been published on 3rd of April 2024 in the Nature newspaper.

Dr. Habil. Ravi Kant

The study sheds light on the impact of a specific gene variant originating from the Viking age on mitochondrial function and cellular antiviral defence responses. Led by academy professor Anu Suomalainen from the University of Helsinki, the research team reveals that this variant, affecting the mitochondrial POLG enzyme, leads to compromised immune defence against viral infections. Consequently, affected individuals may experience delayed and intensified inflammatory reactions, potentially damaging the brain and liver.

The findings highlight the intricate connection between mitochondrial dysfunction, viral infections, and the manifestation of neurological diseases, such as mitochondrial recessive ataxia syndrome (MIRAS). Notably, the age of onset and severity of MIRAS vary widely, suggesting the involvement of additional triggers. Through comprehensive model systems, the researchers demonstrate how the POLG variant weakens initial immune activation, leading to delayed and exaggerated inflammation.

As part of the IDUB program, Dr. Habil. Ravi Kant holds the position of an associate professor at the Institute of Maritime and Tropical Medicine of the MUG. His scientific interests include the search for new and re-emerging pathogens, as well as research into the variability and evolution of viruses. Dr. Habil. Kant is a Principal Investigator and Adj. Associate Professor (docent) at the Department of Virology at the University of Helsinki. In April 2023, the Medical University of Gdańsk signed a letter of intent to strengthen the cooperation between the two units. The collaboration between the Department of Virology and the Institute of Maritime and Tropical Medicine is coordinated on behalf of MUG by Prof. Maciej Grzybek, the Rector’s Plenipotentary for the Development of IMTM

photo by Paweł Sudara/MUG